In the accelerated phase, there may also be acquisition of additional cytogenetic abnormalities and an increase in the proportion of immature cells in the blood or marrow.
Demographic characteristics did not differ among those with and without PFT abnormalities; however, the proportion of current smokers was almost threefold higher in patients with PFT abnormalities compared to the group without (22% vs. 8%, respectively; P = 0.012).
The Jonckheere-Terpstra test was used to test for a monotonic trend across doses in the proportion of post-baseline visits with any laboratory abnormality among the total number of post-baseline visits.
Further, there was no difference in the proportion of lab abnormalities as a function of dose group or adjuvant (data not shown).
Abnormalities in the frequency of B cells and in the proportion of different B-cell subsets in autoimmune diseases have been previously reported [ 22, 23].
34 35 Therefore, the reduction in abnormalities after HPV vaccination is expected to increase with increasing severity of abnormality, and thus the proportion of abnormal cytology outcomes with an underlying high-grade CIN is expected to be lower for vaccinated than for non-vaccinated women.
Disturbances in spermatogenesis give rise to sperm morphological abnormalities, although a wide range of sperm abnormalities may be acceptable for normal stallions if the proportion of spermatozoa with normal morphology is above 50% [ 7, 8].
Abnormalities in hormone serum levels and in the proportions of various lymphocyte subpopulations have been found in a number of tumors [ 10].
A tumour was considered to carry a numerical abnormality for a given chromosomal region when the proportion of cells displaying an abnormal number of hybridization spots for the corresponding probe was at a percentage higher or lower than the mean value plus two standard deviations (SD) of the mean percentage obtained with the same probe in control samples (n = 10).
Fluorescence in situ hybridization (FISH) is more sensitive for recognizing specific chromosomal changes in quiescent cells and increases the proportion of detection of chromosomal abnormalities in MM up to more than 90%.
