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Specificity of VPT was greatest for abnormal nerve conduction.
VPT values that provided ∼80% specificity were 2.61 for definite clinical neuropathy, 2.34 for abnormal nerve conduction, and 3.31 for confirmed clinical neuropathy.
AUC was higher for older participants: 0.78 vs. 0.71 for definite clinical neuropathy, 0.78 vs. 0.75 for abnormal nerve conduction, and 0.83 vs. 0.76 for confirmed clinical neuropathy.
The PPV of VPT was higher for abnormal nerve conduction (76%) than for definite (49%) or confirmed clinical neuropathy (43%) and increased with age (Table 3).
Specificity of VPT was highest for abnormal nerve conduction (62%) and lowest for definite (51%) or confirmed clinical neuropathy (51%) (Table 3).
NPV was higher for confirmed clinical neuropathy and definite clinical neuropathy and lower for abnormal nerve conduction, reflecting the lower prevalence of the confirmed and definite clinical neuropathy.
Similar(52)
Severity of DSP was defined according to the number of abnormal nerve conduction parameters.
The current reference definition for DSP is based primarily on large-fiber tests of the long nerves the results of clinical evaluation and the presence of abnormal nerve conduction studies (28).
Listen for abnormal heart sounds.
For the full cohort, VPT values that provided ∼80% sensitivity were 4.30, 3.55, and 4.29 for definite clinical neuropathy, abnormal nerve conduction, and confirmed clinical neuropathy, respectively.
Moreover, they support the validity and utility of our proposed definition for abnormal median nerve conduction.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com