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The L. interrogans genome codes for a wide array of potential diguanylate cyclase (DGC) enzymes with characteristic GGDEF domains capable of synthesizing the cyclic dinucleotide c-di-GMP, known to regulate transitions between different cellular behavioral states in bacteria.
Although gaining a reputation in recent years as "frequent hitters" in screening programs, rhodanines as well as their bioisosteres, 2,4-thiazolidinediones and the hydantoins, remain attractive tools to medicinal chemists for structural manipulations directed at developing potent and selective ligands for a wide array of potential molecular targets.
We investigated the association between sleep duration and weight, adjusting for a wide array of potential confounders.
The multinomial logistic regression, adjusting for a wide array of potential confounders (see footnote in table 5), supported the descriptive results.
For each health and well-being outcome we report ORs and 95% CIs using multinomial logistic regression adjusting for a wide array of potential confounders.
In addition, in the current analysis, we controlled for a wide array of potential confounders, such as socioeconomic status (as represented by the educational attainment of the nurses and their husbands) and demographic, lifestyle, and dietary risk factors.
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Natural compounds provide a wide array of potential drug candidates for cancer therapy with various roles and targets [ 40, 41].
For example, the existing heterogeneity among children with disabilities implies a wide array of potential capacities alongside an awareness of vulnerabilities that need to be explored.
Intensive care unit (ICU) patients also are exposed to a wide array of potential nephrotoxic agents, which increases the risk for vancomycin-associated nephrotoxicity.
Yet a wide array of potential investors has been whittled to one.
It also involves exploring a wide array of potential solutions that are prized by people of varying worldviews.
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