First, for each of the O cL) base pairs (a i, a j )∈𝒞, there are O d) aligning partners for a i and O d) aligning partners for a j, giving a total size of O cd2 L ).
Alternatively, for each of the O dL) aligning pairs (a i, b k )∈𝒞, there are O c) base-pairing partners for a i and O c) base-pairing partners for b k, giving a total size of O c2 dL ).
Using the same criteria, we established that the baseline mean±SD AQLQ score for the eligible group is 4.60±0.91, and using the same parameters, a clinically significant increase of 0.5 38 in AQLQ would require a sample size of 52 patients/group for a total sample size of 104.
We determined that with a power of 90%, alpha of 0.05, the required sample size per each group is 21, for a total sample size of 42 participants.
Therefore, our final estimated sample size will be 220 patients per arm, for a total sample size of 660 patients.
Given the large number of patients who qualified for the study, in the end we studied 134 statin non-users and 31 statin users for a total sample size of 165, which is a significantly higher sample size than originally estimated (ie, N=165 vs 122).
Thus the expected sample size is 425 elderly people in each of 6 countries for a total sample size of 2550 individuals.
Following the screening, 50 BSS, 100 OCR and 100 CCT abstracts were randomly selected from each year using computer assigned random numbers, for a total sample size of 1,000 Each abstract in the sample was reviewed in detail as to study design, sample size and statistical significance of the study results.
On the basis of this analysis, we had aimed for a total sample size of 111.
On the basis of this analysis, we aimed for a total sample size of 159.
