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An effort by Cephalon to have the drug approved for a third indication, excessive sleepiness from any cause, was rejected.
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The organization stated that "a biosimilar proven effective and safe for one indication may not necessarily be effective and safe for a second indication for which the reference biologic has been shown to be safe and effective".
For a first indication of whether it would be possible to perform selective chemistry on either of the two phosphorus heteroatoms, PPAs 5 a– c were subjected to oxidative conditions by using an excess amount of sulfur in CH2Cl2.
Unfortunately, by the time a new drug is approved for its first indication, there is typically less than 10 years on the original 20 year composition-of-matter patent remaining, 7 which is not enough time to generate the data needed to approve the drug for a second indication and make a profit.
A company can test individual drugs for second targets within the same indication or find a second indication for the drug.
"If foreign banks are cutting credit lines for corporates, that could be a first indication of a credit crunch," Mr. Potter said.
Hypothesis testing of the developed propositions should be a first indication for future research endeavors.
These results might be interpreted as a first indication for the importance of evolutionary history knowledge as a context for the development of evolutionary explanations.
Note that E-RAB Retainability gives a first indication for areas with lack of LTE coverage that are not covered by any uRAT.
The research presented in this paper offers a first indication for the importance of such process-based research that should be complemented by additional and more detailed studies in the future.
A first indication for the protein nature of this receptor and its molecular weight emerged from cross-linking experiments applying several cell types and revealing two distinct complexes representing 110 and 150 kDa proteins associated with the heparanae C-terminus domain (C-domain) [57].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com