Sentence examples for for a substantial problem from inspiring English sources
"She has undergone recent surgery and is in the middle of a rehabilitation period for a substantial problem, though a problem she can recover from.
Failure to follow up test results for hospital patients is a substantial problem.
In contrast, Estoup et al. [ 22] concluded that size homoplasy is not a substantial problem for population genetic studies, except for highly mutable microsatellites with strong allele size constraints in large populations.
While the targeted approach has produced some notable successes, such as for chronic myelogenous leukemia, the development of resistance is a substantial problem, particularly for more advanced (and hence complex) cancers (Daley 2003; Bunn 2007).
From a global perspective, right now we are building up a huge problem in the west with our net debt and this is a substantial problem for development.
Because of the high cost of so many films, many studios have been eager to thwart film piracy, which is a substantial problem for American films in Asia.
Methyl mercury, the toxic form, even poses a substantial problem for the Arctic, she said, because it can accumulate in polar bears and seals.
"Discrimination continues to be a substantial problem for too many job seekers and workers, and we must continue to build our capacity to enforce the laws that ensure that workplaces are free of unlawful bias," the commission's chairwoman, Jacqueline A. Berrien, said in a statement.
If it proves to be a substantial problem for the company, it could burst Google's bubble as well as the rest of the Internet ad business.
