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To be sure, identifying terrorist activities is quite different than gathering evidence of child pornography – in the former, the goal often is to prevent an imminent attack, so there likely is less concern about evidentiary issues for a subsequent trial (if one would ever occur).
This information reflects the effectiveness of the intervention and the 'noise' in the measurement (precision of the measure) and together with the other information will inform the choice of primary outcome for a subsequent trial.
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A significant and clinically relevant improvement in these parameters would provide a solid rationale for performing a subsequent trial testing histological improvement.
In his letter Shinton highlighted several concerns with the initial trial used to obtain marketing approval for alteplase 3 and a subsequent trial that was key to extending its window of use in Europe from three to four and a half hours.
Putting merely a statement that the margin was determined based on clinically acceptable difference is not sufficient for any subsequent trial replications.
The new item on one trial became an old item for all subsequent trials.
Although it was a pilot trial to inform the design for a subsequent definitive trial, the findings suggested that compared to usual care, participants' pain levels, as measured by the chronic pain grade (CPG), improved in both pharmacist-led intervention groups, particularly in the group managed by pharmacist prescribing.
Based on these results, broadband power and weighted SNR were selected as features for a subsequent clinical trial.
These data will, however, be informative in determining power for a subsequent randomised trial.
A prospective economic evaluation will be rehearsed to develop and refine methods for a subsequent definitive trial.
The two patients with tumours positive for BRAF mutations were identified through screening for a subsequent clinical trial of the BRAF inhibitor PLX-4032 (NCT00949702).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com