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The old concept of developing selective agents for a single target does not fit with the medical need of most neurological diseases.
Currently, drug discovery is largely based upon a "one molecule - one target - one disease" philosophy and many successful drugs, that are selective for a single target ("magic bullets"), have emerged from this strategy.
Even though by extension it is often referred to as "ligand efficiency", the concept was originally conceived to be strictly applicable to comparing the binding efficiencies of ligands for a single target.
In addition, it was revealed that the discharge that yields the maximum Weighted Usable Area (WUA) for the whole fish community is more than twice the discharge yielding the maximum WUA for a single target species.
Using these methods, we report nuclease-mediated indel rates of up to 94% in Jurkat T cells and 87% in induced pluripotent stem cells (iPSC) for a single target.
We examine the deviation between the ordered case and OoS case for a single target.
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There remains a need, however, for high-throughput alternatives to traditional Sanger sequencing for repetitive analysis of a single target and for analysis of a small number of targets in multiple samples.
This plateau effectively represents Ct value for amplification of a single target molecule.
Following the three initial primers, 27 primer sets were tested for amplification of a single target by agarose gel electrophoresis and sequencing.
For the treatment of multifactorial and complex diseases, it has become increasingly apparent that compounds acting at multiple targets often deliver superior efficacy compared to compounds with high specificity for only a single target.
The idea of minimizing a scalar function of the predicted error covariance was also applied in moving all sensors in a network for tracking a single target [2, 3, 12].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com