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Replication origins are 'licensed' for a single initiation event before entry into S phase; however, many licensed replication origins are not used, but instead remain dormant.
In late mitosis and G1, MCM2 7 complexes are loaded onto replication origins to 'license' them for a single initiation event (Blow & Dutta, 2005; Machida et al, 2005; Arias & Walter, 2007).
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These hairs arise from a single initiation site.
Dll4 allelic deletion reduced papilloma latency and promoted their multiplicity and growth, although without affecting malignant progression of these lesions.> -wrap-foot> Reshown shown are from 182 lesions from WT and Dll4 +/− littermates (n = 12 for each group) treated with a single initiation dose of 25 μg DMBA followed by 4 μg TPA twice a week for 19 weeks.
In the baseline scenario, we estimated the total number of doctor-months required for universal coverage by: 1) measuring the time taken for a single treatment initiation; 2) multiplying this by the number of required initiations; and 3) dividing this by the number of work hours in a month.
A simpler interpretation of our data is that, at least in chicken, rho and epsilon are not competing for a single transcription initiation promoting complex.
This effect was even more striking for genes with a single transcription initiation site (without ATI).
Molecular evidence is lacking for a single master switch controlling ripening initiation, such as the established role for ethylene in climacteric fruit ripening.
Even though the risk is extremely low for a single cell, the probability of cancer initiation will rise with increase of both life span and body size (i.e., number of cells).
A numerical finite element study is performed for a single edge notch specimen, to investigate the influence of initiation locations on the accuracy of the method.
Typically, there are few intergenic nucleotides except for a single large non-coding region generally thought to contain elements that control the initiation of replication and transcription [ 2].
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