The majority of published studies [ 10, 11, 21, 24] evaluated the discriminative power for infection diagnosis of a single determination of a particular marker.
The potent cytotoxicity of 9 was confirmed in IC50 assays with authentic compound (Table 2), which demonstrated a similar potency to the 2-hydroxylamine 8 (not detected as an extracellular metabolite) and a higher potency than any of the CB 1954 metabolites in all cell lines (except AA8, in which case 9 and 4 were similar, based on a single determination for 4).
It may be questioned whether it is appropriate to use a single determination for levels of vitamin D. However, it is reassuring that a recent cohort study that measured 25OHD3 at 2 times, 3 years apart, found a high correlation between levels.
If the development of a water supply is for a single purpose, then the determination of ownership may be relatively simple; but if the development is multipurpose, as most modern developments are, ownership may be difficult to determine, and agreements must be worked out among countries, states, municipalities, and private owners.
While 30 ETV firings were used for a single efficiency determination, reasonable precision could be obtained with approximately 10 firings while still employing reasonable analyte masses, i.e. approximately 20 ng.
He was also noted for a single-minded determination to write music full time, without the long-term teaching commitments many composers typically assume.
For example, a single spirometry determination of FEV1 (forced expiratory volume in one second) is recognized to have very limited diagnostic value, whereas cross-shift spirometry is "insensitive" (Balmes, 1991; Bernstein et al., 2006a; Burge, 1982; Nicholson et al., 2005).
Optimizing the cut-off level for a single serum hCG determination around day 15 after oocyte retrieval or ovulation.
Thus, for single determination, less than 0.02 mL of blood was required.
