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The slight increase in the size of the residuals for a separate validation period was considered acceptable (NSL in the range 0.60 0.89 for daily flow and 0.10 0.74 for nitrate concentration, excluding one data set with limited validation data).
It has been shown to estimate model performance more accurately than other approaches such as those that involve setting aside data for a separate validation sample.
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In the absence of a separate validation cohort, leave one out cross validation was performed for this model (miR-200b + c) and gave an identical AUC value.
The best strategy for performance comparison would be to use a separate validation set for accessing the performance of prediction models.
Ergo, it does not allow a separate validation for the two dimensions.
A separate validation procedure is recommended for Haglund's disease and insertional Achilles tendinopathy patients.
A separate validation study showed this method for stroke ascertainment had high positive predictive value of 94% (unpublished data).
This provided weightings for the score, which was then simplified and tested on a separate validation group by receiving operator characteristic (ROC) analysis and goodness-of-fit tests.
The patients could be considered as a separate validation population.
Thus, cross-validation is performed internally and there is no need for a separate cross-validation data set to obtain an unbiased estimate of the test set error.
New field data collection will permit further validation of the system as a whole, and for the separate validation of each sub-model that makes up the overall modelling environment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com