This role of the sirtuins is most likely conserved also for yeast Sir2 [60] and, as such, it may provide a first clue for the difference in synphilin-1 instigated toxicity between ageing wild-type cells and ageing sir2Δ cells.
This is particularly noteworthy as it is a first clue for the influences of fast stress reactions independent of the second wave.
A first clue for how to explain this discrepancy emerged when we tested two PICH mutants for their ability to restore normal mitotic timing in PICH-1 siRNA-treated cells.
A first clue for a functional role of this tumour specific downregulation became evident when comparing the expression levels of the proapoptotic TRAIL-variant with the non-proapototic isoforms (TARIL-β and -γ), showing a tumour specific increase of proapoptotic TRAIL-α.
This observation provides a first clue for understanding the independence of translatome changes by the transcriptome: following cell stimuli which act on their expression, many genes coding for components of the translational machinery do not undergo any change in their mRNA levels, but only variations in the rate of polysomal loading of these mRNAs.
This result was surprising, because proteasomal degradation should result in total decomposition of GFP-CL1 and provided a first clue for the degradation of the CL1 degron sequence by autophagy since the GFP part remains and is not, or only slowly, degraded by vacuolar proteases.
Feeling disheartened, we ask for our first clue from the facilitators, which helps us with one of the puzzles, rendering us able to open a drawer containing a deck of cards.
At Citigroup, Goldman Sachs and Morgan Stanley, for example, the first clue that someone is gone can be e-mail messages that are returned to senders from a former colleague's inactivated corporate address.
The fact that this Neapolitan pizzeria is named after a Dominican friar burned at the stake for heresy is your first clue that Bruno wants to bend the rules.
WHEN looking for deluxe overnight lodging, the first clue that a place might pamper you is valet parking.
