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These studies provide evidence for a robust effect of XY sex chromosome complement to decrease expression of genes related to fast inhibitory GABA signaling and neuromodulatory serotonin and dopamine signaling.
Each failsafe N (580 for studies evaluating overall mortality as main outcome, 68 for studies with cardiovascular mortality as main outcome, 72 for incidence of or mortality from cancer, and 43 for incidence of degenerative diseases) far exceeded Rosenthal's recommendation (failsafe N>5k+10, where k is the number of studies included in the analysis) for a robust effect of the overall analysis.
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Taking gender into consideration, the ES (0.51) remained statistically significant for women, still suggesting a robust effect.
With the large number of high quality trials, they were able to find a robust effect of acupuncture for each condition, which was superior to both sham and no-acupuncture control groups.
"I'm all for a robust placebo effect," Mr. Wyatt said.
In particular, if such a retrospective validation can be demonstrated in data from two independent RCTs, this provides a strong evidence for a robust predictive effect (Mandrekar and Sargent 2009).
Similarly, in an experimental model which uses a 48 h application of 0.1% w/w capsaicin cream under occlusion to induce nearly complete loss of immunostaining for ENFs and a very robust effect on dermal nociceptors, no effect on wound healing has been reported in PDN and HIV-AN patients after repeated 3 mm punch biopsies in capsaicin-treated areas on the leg.
In a series of multiple logistic regression models, we tested whether unemployment change and the occurrence of a birth in East Germany in 1991 showed a statistically significant and robust effect on the odds for a male birth.
The temperature increases reached after 2 min were large enough for a robust quantification of the effects but small enough to keep the required cool-down periods between two successive experiments sufficiently short to allow the realization of this study.
The additive effect was more robust effect for visuospatial than for verbal stimuli, and more robust for negatively than for positively valenced stimuli.
As expected for the P3 at the central electrode cluster, a robust main effect was found for Inhibition, F 1,36) = 138.85, p<.001.
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