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We have comprehensively evaluated the VORESCORE method for a range of alignment and threading methods.
While early approaches relied on estimating an inverse covariance matrix (Marks et al., 2011; Morcos et al., 2011; Jones et al., 2012), more recent studies have shown that a pseudo-likelihood-based approach (Balakrishnan et al., 2011) results in more accurate predictions (Ekeberg et al., 2013; Kamisetty et al., 2013) for a range of alignment sizes and protein lengths.
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For structure alignments, the techniques are very fast, reliable and tolerant of a range of alignment parameters.
(iii) a range of alignment columns to which the search for shared k-mers is restricted.
We developed and applied methods that used a range of alignment parameters with increasing permissiveness in terms of gap characters present within an alignment.
Moreover, MAFFT offers a range of multiple alignment methods including alignment of a very large number of sequences, a feature needed either for very large multigene families or when a large number of species is employed.
During this process, the maximum-likelihood algorithm considers for each particle a broader range of alignment possibilities, each weighted by a certain profile.
Folk vote for a range of reasons.
Be prepared for a range of reactions.
Be prepared for a range of emotions.
Because MotIV uses the STAMP source code, it provides a range of options for alignment calculations (see the documentation for the R package and/or STAMP).
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