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At LAX airport, I was selected for a random screening.
"There are still some very, very nice T.S.A. agents, so I don't want to generalize," Mr. Kapson said, "but it seems like occasionally, you come across this agent that's -- I don't want to say power hungry -- but they're on this kick like, 'You'll do what I say or you're not going anywhere".' He described an incident when he groaned, "Oh, man," as he was pulled aside for a random screening.
"You've been selected for a random screening".
Similar(57)
A random screen for Dictyostelium mutants identified Kil2 as another essential gene for efficient growth on Klebsiella.
Although we do not see enhanced tumor growth mediated by cdr2 in EL4 tumor cells, a random screen for focus-forming genes in NIH3T3 cells [54] categorized cdr2 as "moderately" oncogenic.
I proposed a theoretical framework for random screening trials and concluded that the application of the results from an individual trial should be limited to the regions where similar diagnostic practices are observed.
Direct testing of these known inhibitor classes can reduce the requirement for large, random screening campaigns, and provide an entry into chemotypes that have been already shown to be drug-like, and able to be advanced into clinical trials (often referred to as "privileged" structures").
We conclude that direct measurement of fluorescence intensities after transfection of cells with a labelled HIV derivative represents a reliable method for monitoring HIV particle release, which is suitable for use in random screening approaches to search for chemical inhibitors or siRNAs specifically interfering with HIV assembly or release.
This methodology is nontoxic, uses a thermally-stable reagent and is suitable for random screening of the antimycobacterial activity.
Further adaptation to a multi-well format rendered the assay suitable for medium or high throughput screening of siRNA libraries to identify host cell factors involved in late stages of HIV replication, as well as for random screening approaches to search for potential inhibitors of HIV-1 assembly or release.
Further adaptation of the assay to a semi-automated multi-well format was performed to render the assay suitable for random screening.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com