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16 After 48 weeks of treatment, this study showed a noninferiority of once-daily NVP-XR 400 mg compared with twice-daily NVP-IR, for a predefined margin of −10%.
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The primary analysis tested the hypothesis that the occurrence of all-cause serious adverse events for Usual Diabetes Therapy (UDT) plus Cycloset™ is not inferior to that for UDT plus placebo by a predefined margin.
For this study, the predefined margin of non inferiority was defined as a hazard ratio (UDT plus Cycloset® versus UDT plus placebo) of 1.5.
The primary endpoint was ORR by independent review with a predefined equivalence margin of 15%%.
Efficacy analysis at 48 weeks demonstrated that MVC b.i.d. was not noninferior to EFV for the primary endpoint of viral load below 50 copies/ml (65.3 vs. 69.3%), with a predefined noninferiority margin of 10%.
Then, it should open its doors and set an alarm for a predefined amount of time.
This scheme is repeated for a predefined number of iterations n.
Maximum time: max_timeMaBoSS produces trajectories for a predefined amount of time, set by the parameter max_time.
d) The algorithm iterates for a predefined number of steps or until convergence.
Run the process for a predefined number of steps and pick the one with the highest score and minimum inconsistency.
RBT-GA's optimization process is terminated when no improvement is met for a predefined number of iterations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com