[ 16, 30- 36] Because of mass spectrometry's peak interpretation and reproducibility challenges [ 37, 38], scientists have searched for breast cancer biomarkers from predefined collections of known candidate markers using newer multiplex technologies, such as reverse-phase protein microarray [ 39].
The following information was collected in a predefined data collection form: first author's name, publication year, country, sample type, total number of cases and controls, quantitative methods, and publication language.
Data from qualified studies were collected by two independent investigators, using a predefined data collection table.
A case report form and study manual were created for data collection, definitions, and a predefined list of acceptable antibiotic(s) for each site of infection (Additional file 1).
The redesign of enzymes to produce catalysts for a predefined transformation remains a major challenge in protein engineering.
Previous use of oral bisphosphonates was allowed, provided criteria for a predefined washout period were met.
Although the sensitivity and specificity of TaqMan assays is far greater than for spotted arrays, each assay is highly specific for a predefined, mature miRNA sequence.
For multivitamins, patients may choose from a predefined list of popular brands of multivitamin (Centrum, etc).
As a first step, we suggest having a predefined list of keywords to search for on the crawled web pages.
