These findings imply that PROSPERO, in addition to its known role as cell fate determinant in GMCs, provides a transient signal to ensure a precise timing for cell cycle exit of prospective neurons, and hence may link the mechanisms that regulate neurogenesis and those that control cell cycle progression in postembryonic brain development.
In conclusion, the occurrence of SDDP requires a precise timing between pre- and postsynaptic activities.
Therefore, the AAI monitor may be an useful tool to determine a more precise timing for the electric shock of ECT.
An exciting extension of this methodology would be to adapt it for high-throughput drug screening, such as by epifluorescence imaging in 96-well glass-bottomed culture dish format, with robotics to control the field of view in each well, and employing a microfluidic device for precise timing of drug delivery in each well.
Further sequencing of a broader range of ancestral craniata is required to identify a more precise timing for the duplications.
Thus, active, natural vision with its frequent and self-initiated eye movements can make use of an effective mechanism for precise timing of spikes and synchronization of spikes between neurons, thus affecting downstream neurons efficiently (Abeles 1982; Alonso et al. 1996; Usrey and Reid 1999).
With their demand for precise timing and quick reaction times, and often foreknowledge of what's to come, success is often a case of repeating the sequence enough times that you've learned the exact button presses required.
To evaluate the different reactive stopping models we tested a group of subjects (N = 60, see Materials and methods section) on a modified version of the stop-signal task that allows for precise timing of the target response time (RT) (Coxon et al., 2012; Lappin and Eriksen, 1966; Zandbelt et al., 2013).
Furthermore, this external development allows for the precise timing and dosage of ethanol exposure.
