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Thus, differences in genetic sequences can be the primary determinant only for a modest fraction (typically 10%20%%) of TF binding differences between these mammalian genomes.
Second, although SNVs in and near directly bound motifs may be responsible for a modest fraction of these differences, other influences appear to play a larger role (Bradley et al., 2010; Kasowski et al., 2010; Reddy et al., 2012).
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Imagine, if you will, if you needed to make use of a modest fraction - say 2% - of those patents to develop a new pharmaceutical product.
The narrow extent of reactivation implies that the majority of transcription factor recognition sequences are not competent for binding even in the absence of methylation, and that methylation accounts for only a modest fraction of cell-selective binding.
Why would you be willing to work so hard and take so much risk for only a modest fraction of ownership?
Common variation accounts for only a modest fraction of the predicted heritability and the role of rare genetic variation of higher effects (ie, odds ratios markedly deviating from 1) is increasingly being identified through sequencing efforts.
However, the joint contribution of genetic variants has to date accounted for only a modest fraction of the recognized etiologies [4].
For many diseases, recognized risk factors account for at best only a modest fraction of variation in disease risk.
However, it is likely that common variation will explain only a modest fraction of heritability for early-onset obesity (for example FTO, the strongest predictor of obesity, is responsible for only 1% of the total heritability) [ 139].
Despite successful utilization of genome-wide association studies (GWAS) to identify susceptible common variants for a variety of complex diseases [4], only a modest fraction of phenotypic variation has been accounted for by the identified variants.
The kidney is responsible for the bulk of potassium excretion but a modest fraction of ingested potassium may be excreted by secretion in the colon.
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CEO of Professional Science Editing for Scientists @ prosciediting.com