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This ostensibly minor technical feature accounts for a major effect: the uncanny play of light and shadow along the columned façade as the sun rises and sets, which, as one member of the restoration teams has put it, can make it seem that every day "the Parthenon is moving into the light".
The two backcross datasets both provide support for a major effect of the X chromosome.
For a major effect QTL, threshold values of Z for the three BC1 populations were determined by permutation tests with 10,000 trials [ 18].
In maize, zfl2 is the candidate gene for a major effect QTL controlling the whorled versus two-ranked arrangement of female spikelets in maize versus teosinte.
The major conclusions drawn from this study are that, the LDLR g.3131C > T polymorphism in the 5' region of the LDLR is responsible for a major effect on LDL-C concentration because of the increase in the transcriptional activity of the LDLR gene, and also indicates that the LDLR variation is associated with PH.
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Thus, the detection of a major effect QTL for late blight resistance on the long arm of chromosome 9 of "Jacqueline Lee," along with the identification of a candidate SNP (solcap_snp_c1_10590) associated to this QTL, provides strong evidence for the location of genes controlling the trait.
Therefore, it could be argued that, for prediction purposes, it may be crucial to consider IGR for complex traits, although this may be less important for regions with a major effect on phenotypes.
The utility value attributed to taking pills for prevention can have a major effect on the cost-effectiveness of interventions, but few published studies have systematically quantified this value.
Weather, for instance, has a major effect on the payment rate.
And officials from Medtronic and Boston Scientific, as well as many doctors, say more clinical data supporting the test's predictive value is needed for it to have a major effect on everyday medical practice.
James Blumenstock, chief of health security for the Association of State and Territorial Health Offices, said a major effect of this kind of declaration is getting money from a FEMA-managed fund into communities right away, and making sure local governments get reimbursed for extraordinary expenses.
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