Third, although measurement of the d-ROMs and BNP is feasible for the assessment of oxidant status in a large scale population, different association between renal parameters and oxidant status biomarkers may be obtained according to the types of oxidative stress measurement used [ 32].
Several genetic and environmental differences as well as causes of death between Japanese and Western people exist and in the present study we examined the association between diagnosed diabetes and premature death for Japanese general people in a large scale population-based cohort study.
Therefore, there is a need for a large scale, population-based, survey of psychiatric disorders in the whole country, using a detailed diagnostic interview to assess the prevalence and associations of common mental disorders and harmful substance use.
The pilot study demonstrates feasibility of a large-scale population-based screening programme for RHD by the use of portable echocardiography, with a subsequent prospective cohort study.
But it is still too expensive for detecting CNVs in a large-scale population.
Furthermore, our data permit refinement of carrier frequency and detection rate information for six major ethnic groups and the general, pan-ethnic population and address the call for a large-scale population screening study.
For instance, a large-scale population genomics study of the malaria parasite Plasmodium falciparum (Apicomplexa), involving the sequencing of complete organelle DNAs from 711 distinct isolates, exposed ∼4 times more polymorphisms per silent site in the mtDNA as compared with the ptDNA (Preston et al. 2014).
The HIV-1 pol-genotyping assay presented here is a sensitive, robust and subtype generic tool for a large-scale population-based HIV-1 drug resistance surveillance for the use of DSS/DPS.
However, to correlate individual level cardiac responses with a surrogate of location-specific exposure, our approach represents one of the best available methods for a large-scale population-based study.
In Israel, among women electing carrier screening for cystic fibrosis and fragile X syndrome, a large-scale population screening study found 93% requested SMA testing as well.
The ability to detect mutations by HRM alone has implications for economical large scale population screening studies to understand the prevalence and characteristics of other known or suspected founder mutations.
