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For a global validation, we pooled targets from multiple ChIP datasets and pooled context-specific predictions for each of three TFs.
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The dust indicators and records of terrestrial and marine palaeoenvironments (DIRTMAP) database was designed to serve as a global validation data set for use with earth system models of the palaeo-dust cycle.
Miron et al have demonstrated that the popular strategy of selecting genes with the greatest fold-increase generally fails as a global validation strategy while a random selection of genes for validation (10 25 genes) is a more robust technique [ 25].
This paper presents a generic discrete continuous simulation model for an accurate global validation in heterogeneous systems design.
Some would argue it is cringeworthy to make such a song and dance of Australia's international artistic success, because it makes the country look desperate for global validation.
For all information pertinent to RT-qPCR validation of microarray results see Additional file 4. Microarray and qPCR fold changes (FCs) among all five tissues for ten target genes were compared in Log2 space using the concordance correlation coefficient (CCC), proposed for global validation of microarray experiments [ 54].
The method was validated to meet requirements for a global regulatory filing and this validation included specificity, precision, linearity, accuracy and range.
Results section: 5) It would be good to have confidence intervals for the model outcomes for the high incidence scenario (global validation).
Given the lack of a consensus gold standard for methylation quantification, we consider that the global validation of the Methylation array Platform results with an additional technique (57 90%) was quite appropriate but far from perfect, indicating that a validation would be especially relevant for each potentially pathogenic aberration.
Results from global validation datasets provided an average overall accuracy higher than 0.95.
This study also presents the in situ LAI measurements for further validation of global products for areas that are currently under-represented in Earth Observation (EO) global validation networks.
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