Just a year after Georgina's birth, Sant got pregnant after a further three cycles of natural-cycle IVF.
She had a partial response after two cycles, which was sustained on CT scan after a further four cycles of treatment.
Five patients completed six courses of treatment, of whom two continued on temozolomide alone (at 1000 mg m−2) for a further six cycles.
In phase B, matuzumab plus ECX was continued on the DL selected in phase A until disease progression, unacceptable toxicity or for a further six cycles.
In patients who responded or who developed stable disease (SD), the treatment was continued for a further eight cycles, and the response assessment then repeated.
For cycling studies, SCN and lung slice cultures derived from WT and CK1ε−/− mice were maintained for 7 days on 12 hr, 36°C/12 hr, 38.5°C temperature cycles, after which the cycle was reversed and maintained for a further nine cycles.
Responding patients or those with stable disease could continue treatment for a further four cycles of intermittent chronomodulated therapy with assessment of tumor response after four and six cycles (day 85 and 127, respectively).
If a patient continued to have SD or a response, then treatment could be continued for a further eight cycles, that is, up to a maximum of 24 cycles of chemotherapy.
The chemotherapy component of the definitive chemoradiotherapy was identical to the induction chemotherapy regimen above continued for a further two cycles (i.e., from day 43 to day 84).
Our group has therefore initiated a phase III trial in which non-responders to two cycles of docetaxel, doxorubicin, and cyclophosphamide are being randomly assigned to either continuation for a further four cycles or to four cycles of a non-cross-resistant regimen consisting of vinorelbine and capecitabine [ 29].
In another pilot trial, 133 patients with large (> 3 cm) or locally advanced tumours and a clinical response to four cycles of cyclophosphamide, vincristine, doxorubicin and prednisolone (CVAP) were randomly assigned either to continue for a further four cycles with CVAP or to four cycles of docetaxel.
