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This study asks which index can detect significant deterioration earliest, for a fixed specificity.
A further optimization strategy involves using spaced k-words, which improve the sensitivity for a fixed specificity [ 39].
Splitting sentinel data into separate geographic-based streams and monitoring all 8 streams for 2 or 3 simultaneous aberrations provided substantial improvements in AUWROC and also in timeliness for a fixed specificity when compared with monitoring aggregated data or any single data stream.
For a fixed specificity of 95%%, the highest sensitivity (71%%) was obtained for Aβ42 over ttau.
This is why we tested the optimal cut-off points for a fixed specificity of 75% or 80%.
The sensitivities for each antigen for a fixed specificity of 90% are shown for the unadjusted and adjusted method in Table 3.
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True, Douglas Stein's setting -- a red dirt hill, complete with rocks, holes and bogs -- and Anita Yavich's silent-clown tramp costume have a fixed specificity.
In these calculations, the thresholds c of the continuous biomarker were chosen to demonstrate various possibilities for outcome prediction including fixed sensitivity, fixed specificity, and balanced sensitivity and specificity.
We not only provide the parameters providing optimal balance between sensitivity and specificity but also the parameters that provide an acceptable sensitivity for a fixed high specificity.
When comparing two tests, it is a good practice to select cut-offs that fix specificity at a particular level for both tests, which allows test sensitivities to be compared at equivalent specificities.
As discussed in the results section, varying the bootstrap support threshold b allows users to achieve a smooth tradeoff between sensitivity and specificity for a fixed fold change f (see, e.g., Figure 1).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com