We have used typical parameters of present state-of-art experimental setups in order to identify the required improvements of these setups to allow for a first proof-of-principle experiment.
For a first proof-of-concept test, we prepared barcoded SbfI libraries from two threespine stickleback individuals from a phenotypically polymorphic population (High Ridge Lake, Oregon).
These findings provide a first proof of principle for our recent hypothesis concerning the existence of a measurable activity of Hh signaling in mature hepatocytes [ 18].
However, compared with PA, TO and its prodrug Race induced less potent increases of tumor uptake, highlighting the significance of inhibitor type, administration route, and dose for implementing a first proof-of-principle study in human.
This study provides valuable information and a first proof-of-concept for the feasibility of a Treg-based immunotherapy in the maintenance of disease remission in SLE.
In awarding the prize for physiology or medicine in 1998, the Swedish Nobel assembly praised the scientists for providing the first proof that a gas, despite its inherent instability and ephemeral nature, can perform important biochemical functions in the body.
If you plans to apply there are a few rules: If you win the grant you have to form a legal entity, it's for first proof of concept stuff not existing projects, and it's not to buy hardware/software.
Lulu.com charges about £3.60 for the first proof copy, as long as you have done it on your own, complete with colour cover, after which you pay for add-ons.
For the first proof, you're looking for the dough to double in size.
