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A drug was classified as being "off-label" if the child receiving the prescription had an age below the minimum age as specified in the summary product characteristics (SPC) or the drug was given for a different indication than specified in the SPC.
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Many doctors (Avitzur included) sometimes prescribe a drug off-label — for a different indication, population or age group than those for which it's FDA-approved.
In this case, Dr. Pazdur said, the drugs were already approved for a different indication.
Furthermore, specific probiotics will have different effects in different patients; a probiotic that does not work in one indication may have evidence supporting a beneficial effect in a different indication or for a different symptom.
"Almost every bar has a different indication.
In 50 trials (22.1%), a drug registered in The Netherlands for the same indication/dosage as studied in the trial protocol was used, while 74 (32.7%) used drugs that were registered for a different indication/dosage than studied in the protocol, and 79 (35.0%) used drugs that were not registered in the Netherlands.
IR now caters to many different medical specialists offering a variety of therapies for many different indications.
14, 15 Although our findings of significant and substantial cost savings may appear to conflict with a recent economic analysis reporting increased costs attributable to parenteral nutrition, 19 this previously published economic analysis addressed a different clinical indication for parenteral nutrition than did our CMA.
A total of 232 off-label medicines were administered for 102 different indications.
In rice, for example, the introns are longer and have a higher GC content than in Arabidopsis, which might be an indication for a different impact of alternative splicing in these organisms [ 27, 35– 35].
A medication can receive different FORTA labels for different indications (indication-dependent).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com