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Some subjects needed up to 45 events for a detectable response, while for some others only 10 events proved sufficient.
This may be due to the fact that the evaluation in this study was made after only one fraction, and a reported mean absorbed dose to the spleen of 6.3 Gy, which could be too small an exposure for a detectable haematological response [29].
The model was run using the lm function in R, and from the mean and SD of the normalized values (i.e. the residuals from the regression model) we defined a threshold for a detectable normalized response as t = mean+2SD.
Perhaps an incubation time longer than 19 months is necessary for a detectable accumulation of lymphoid PrPCWD, or a larger dose of inoculum by the oral route is necessary for efficient passage of prions across the alimentary mucosa.
Thus, we removed only the "not-found" spots with high intensity and the spots with no 'detectable' response on any slide, where the distribution of the negative controls was used to define a cut-off for a detectable response as follows: for each slide, we examined first the negative control responses on a scatterplot of the index vs. the log-background[29] to identify and eliminate any outliers.
aCycle Threshold (CT) values over 30 were not considered positive for a detectable signal.
Similar(42)
There were two explanations for the lack of a detectable effect.
In reporter gene imaging, a gene coding for the synthesis of a detectable protein is introduced into a target cell line or tissue via viral or nonviral vectors.
It seems unlikely that the degree or duration of DPPIV inhibition is responsible for the lack of a detectable engraftment effect in our models.
Such collisions will produce a characteristic burst of gravitational radiation, which may be the most promising source of a detectable signal for proposed gravity-wave detectors1.
Findings suggesting the absence of a detectable threshold for neurobehavioral effects in children indicate the possibility of population-wide risks for children from exposures < 5 μg/dL.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com