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We also discuss design considerations for a Correlate of Risk Targeted Intervention Study (CORTIS), which could provide proof-of-concept for the strategy.
Uses for the established threshold for a correlate of protection are numerous.
It was essentially this same method that was employed by Andrews et al. to derive a threshold for a correlate of protection following meningococcal C vaccination [ 22].
A limitation of such data is that the trial will be powered for the efficacy endpoint and will likely be underpowered for a correlate of protection investigation.
The protocol-specified primary analysis for a correlate of protection, in the event that GIA EC50 data could not be estimated for every animal (as was the case here for a number of the animals in Groups C and E), was examination of the correlation between GIA at a fixed total IgG concentration and IVIG.
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Here we have presented preliminary work on the down-selection of assays and methods to be carried forward for investigating a correlate of infection/risk of tuberculosis.
Hair for insulation is a correlate of endothermy, the physiological maintenance of individual temperature independent of environmental temperature.
On balance, the evidence for income as a correlate of men's health knowledge was rated as low.
This study demonstrates the potential for MIG expression as a correlate of protection against malaria.
In adrenalectomized rats, as a correlate for GC depletion, TGF-b1 expression was increased in the hippocampus and correlated with the significant proliferation of newborn neurons [82].
These findings show an empirical relationship between nutritional quality and a correlate for allostatic load [20], or wear and tear [21] during both the nestling and fledgling period.
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CEO of Professional Science Editing for Scientists @ prosciediting.com