The advantage of using identical samples to three complementary approaches allows for a comprehensive comparability.
For a better comparability of the experiments and to avoid different transfection efficiencies, examined shRNA sequences which reached a knock down of at least 80% were stably transfected in a HeLa cell line with a tetracycline-regulated expression (HeLa T-REx).
For a proper comparability of the three fusion kinetics with respect to the distribution of FPs within organelles we go after a similar average organelle size in each case.
Our procedure may help to standardize data acquisition for studies in molecular systematics, allowing for a better comparability between individual results.
For a perfect comparability of such reports the psychological assessment of donor candidates should be conducted in standardized steps as we suggest with our assessment procedure.
However, we used paclitaxel in our study for a better comparability, since this agent had been used in previous studies of HB as well.
For a better comparability of results of the German PAM13 to the American, Dutch, and Danish versions, the psychometric elements of the PAM13 were assessed in two phases.
The effects of the variables were expressed as hazard ratios per 1 SD change to allow for a better comparability between the effect sizes of the different tested variables.
While survival is generally a preferred endpoint in oncology clinical trials, survival endpoints may not be appropriate for a biosimilar comparability trial as they can be influenced by confounding factors such as tumor burden, disease status, and previous lines of therapy.
