The capabilities of the method are demonstrated with the simulation of a common cell-mechanics experiment (a micropipet assay) and a common physiological situation for cell adhesion (the adhesion of two cells under shear flow).
These data point to different cells of origin for each intrinsic subtype, or different stages of developmental arrest for each subtype with a common cell type of transformation, or some combination of the two as different processes may be occurring for each different subtype.
The Cyto-TP was initially tested by depositing fluorescent polystyrene-latex (PSL) nanoparticles on A549 alveolar epithelial cells, a common cell line for inhalation toxicology.
Here, we explored the possibility of detecting human hepatoma HepG2 cells, a common cell model for liver cancer studies, using aptamer TLS11a, which was originally selected through the SELEX method to bind specifically to HepG2 cells and which shows promise for targeted diagnostics and therapy of hepatocellular carcinoma [10, 31 33].
However, the mechanism of multiple chemoattractants with a common cell receptor for guiding cell migration is unclear.
Our initial experiments demonstrated that OT induces CM differentiation of the mouse embryonal carcinoma (EC) P19 cell line, a common cell model for studying early heart differentiation [11].
Sharing common disease profiles for both viral hepatitis-associated ICC and HCC including viral-hepatitis etiology, synergic effects of cirrhosis and age distributions suggests the involvement of similar long-term disease process, and even a common cell origin for carcinogenesis.
CSFV E2 (65% sequence identity) binds to host cells, inhibiting infection by both CSFV and BVDV, implying a common cell receptor for pestiviruses attaching through E2 (Hulst and Moormann, 1997).
Studies in rodents have led to a model in which decreased bone quality in response to TZDs is due to a competition of lineage commitment between osteoblasts (OBs) and adipocytes (ADs) for a common precursor cell, resulting in decreased OB numbers.
In a recent study by Kasimir-Bauer et al. on 502 primary breast cancer patients 46% of CTC positive and 5% of CTC negative blood samples were positive for ALDH1, a common stem cell marker [ 17].
