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Further studies have supported an inhibitory role for Notch in the context of TNFα-induced osteoclastogenesis in the inflammatory setting (Zhao et al., 2012).
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We conclude by discussing whether there is a role for a tunable Notch locus in the context of developmental canalization, particularly in light of distinct bristle patterning phenotypes by equivalent scute inversions carrying different Notch opa variants.
Since loss of Notch signaling and TSLP expression are linked in mouse skin, we assessed a possible role for Notch in the etiology of AD in humans.
A recent study has also investigated other candidate genes that Notch signaling regulates in the context of neurogenesis.
Based on these data and our understanding of Notch signaling, we explored the genetic relationship between Notch signaling and Sox9 in the context of chondrocyte hypertrophy.
So far, we have focused on investigating the role of SMRTER in both the Notch and ecdysone pathways in the context of ovary and wing development.
In Drosophila, Gmd has been studied primarily in the context of Notch signaling, where loss of Gmd blocks expression of Notch target genes and results in reduced growth of the wing disc (Okajima et al. 2005).
In the context of normal Notch signaling, the Notch receptor of the 'signal-receiving' cell is activated in trans by a Notch ligand from a neighboring 'signal-sending' cell.
Here, we discuss our current understanding of Mind bomb structure and mechanism in the context of Notch signaling and beyond.
Consistent with this hypothesis, involvement of Notch signaling in the inflammatory response in the context of wound healing has been described by Outtz et al. (2010).
The functionality of the Clc-GFP has been previously demonstrated in the context of Notch endocytosis in the Drosophila eye (Hagedorn et al., 2006).
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