The data are released as a cell-specific resource, providing a comprehensive expression footprint of the MSCs useful to better understand their cellular and molecular biology and for further investigations on the isolation and biomedical use of these multipotent cells.
Nitrotyrosine expression, a footprint of peroxynitrite-induced injury, has been found at the edge of active multiple sclerosis lesions (Zeis et al., 2009) and is known to mediate oligodendrocyte injury in vitro and in autoimmune encephalomyelitis in vivo (Li et al., 2005, 2011; Nikic et al., 2011; Vana et al., 2011).
Note that ribosome footprints are normalized such that the sum of expression across the time course is equivalent for each gene.
While many genes encoding T. brucei-specific hypothetical proteins also have low ribosome footprint read counts, the majority show higher levels of expression.
Of the 3,030 genes stably expressed between TMs and CMs, only 968 (32%) were concordant (significance cutoff p < 0.05) with their respective genomic imbalance confirming previous estimates [ 19]; we refer to them as "genomic delegates" as they represent in expression the genetic footprint of individual cancers.
From these data, we established an ' autophagy-footprint' of cells expressing ER α or ER β and showed a fundamental difference in autophagy-related gene expression.
The analyses of expression regulatory genomic regions on MSCs allowed us to propose that 11 out of 135 expressed TFs might be upper determinants of the MSC expression footprint.
Such footprints should be studied at the level of functional subclasses of CNSs, such as those which flank genes with a particular pattern of expression.
Moreover, GW3965 significantly reduced tissue nitrotyrosine content (a well-accepted footprint of in vivo nitrative stress, Figure 6, d and e), and inhibited iNOS expression.
The Carbon Footprint of Everything by Mike Berners-Lee.
