The compounds among which, drugs, food compounds, synthetic compounds, and biologically relevant metabolites, were selected from PubChem (Additional file 4: Sheet 1).
Besides, a summary of the most commonly used wall materials and the main encapsulated food compounds are presented.
These compounds cover a wide range of chemical types such as drugs, lipids, food compounds, toxins, phytochemicals and many other natural as well as synthetic molecules.
Consequently, there is clear potential to develop electrospun fibrous assemblies to advance the design and performance of novel products and delivery systems for supplementary food compounds.
Thus, Bt toxins are not likely to be degraded rapidly in the gut and can persist in larger amounts until digestion is complete and there is enough time for interaction between various food compounds.
This chapter focuses on the use and application of nanotechnology concepts for the design of oral delivery systems for the protection, release, and improved bioavailability of nutrients and bioactive food compounds.
These food compounds may act by: (1) inducing apoptosis in cancer cells; (2) inhibiting neoplastic transformation through the inhibition of AP-1 and/or NF-κB activation; and/or (3) suppressing COX-2 overexpression in cancer cells.
Training and evaluation of the ClassyFire program was performed throughout the development of the program, using data sets from several well known databases, containing thousands of drugs [30], lipids [13, 32], food compounds [43], toxins, environmental pollutants, as well as other organic and inorganic compounds.
Interestingly, a number of bioactive food compounds have recently been shown to have anti-CSC effect.
These findings highlight the potential of bioactive food compounds as CSC targeting agent either for the prevention or for the treatment of prostate cancer.
Therefore, bioactive food compounds such as epigallocatechin-3-gallate or resveratrol [4], [5], [6] represents an attractive alternative for prostate cancer chemoprevention, mainly due to their relatively low toxicity.
