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RDI was calculated as follows: (dose intensity/planned dose intensity) × 100.
The flow of NaCl 20% was calculated as follows: Dose NaCl 2 0 % ml ∕ h = Natriuresis × Diuresis × 0. 3 3.
Titration was as follows: dose was increased by 50% if haemoglobin dropped below 10 g/dL or decreased by 25% if haemoglobin was above 12 g/dL.
This adjusted CVVH dose was calculated from the post-filter replacement fluid (RF), pre-filter replacement fluid and blood (blood) flow rates as follows: Dose = Postfilter RF rate + ((Prefilter RF rate × (Blood flow/(Blood flow + Prefilter RF rate))).
Furthermore, of the available studies, the majority are single dose studies, although it has been shown that Methylphenidate follows dose dependent nonlinear kinetics in narcoleptic and healthy patients [ 8].
The doses were then gradually escalated as follows: dose level 2: capecitabine 650 mg m−2 b.i.d. and irinotecan 60 mg/m; dose level 3: capecitabine 825 mg/m b.i.d. and irinotecan 60 mg/m; dose level 4: capecitabine 825 mg/m b.i.d. and irinotecan 70 mg/m.
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Following dose optimization, subjects entered the 2-week double-blind treatment period.
However, the PGE-2 inhibition did not follow dose dependent pattern.
Three trials followed dose adjustment protocols based on serum PTH [ 20, 21, 24] or calcium [ 25].
Following dosing of EtPy at open circuit on Pt and Pd surfaces, adsorption was found to be structure sensitive with extensive chemisorption being exhibited at {1 1 0} and {1 0 0} terraces together with {1 1 1} × {1 0 0} and {1 1 1} × {1 1 1} steps.
Following dosing plan was adapted for the study.
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