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Systemic oxycodone exposure was assessed over an 8-h postdosing interval following topical application.
Dehydroepiandrosterone (DHEA), an endogenous hormone exhibiting poor aqueous solubility, was shown to be effective in modulating skin-aging processes following topical application.
In this study, a novel sustained release proniosomal system was designed using sugar esters (SEs) as non-ionic surfactants in which proniosomes were converted to niosomes upon skin water hydration following topical application under occlusive conditions.
The eight Aloe species had significant anti-inflammatory activity, in addition to the significant acceleration of diabetic wound healing in rats following topical application of the methanol extracts of their leaves.
A novel ocular spectrometer system has been used to evaluate changes in the transmission of ultraviolet (UV) radiation through the anterior eye following topical application of candidate UV-absorbing formulations.
Figure 4a and 4b depicts representative examples of fluorescence microscopy images of vertically cross-sectioned skin following topical application of the above two formulations for 0.5, 2 and 4 h.
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Drug loaded dendritic core-multishell (CMS) nanocarriers are of especial interest for the treatment of skin diseases, owing to their striking dermal delivery efficiencies following topical applications.
Negative results were more likely following topical applications with volatile vehicles (e.g., acetone, ethanol), probably because they allowed the MMA test material to evaporate thereby effectively reducing the applied dose.
Moreover, differentiated keratinocytes in organotypic airlifted three-dimensional cultures were transduced following topical vector application.
Local (subcutaneous and skin), systemic concentrations and organ distribution (liver and kidney) were evaluated serially following topical and oral application of the drug.
These data correlate to earlier published work that collagen type I and type III synthesis is induced following topical vitamin C application.
More suggestions(16)
for topical application
with topical application
continued topical application
following topical applications
of topical application
following dermal application
following topical antiglaucoma
following topical vector
following topical delivery
following anesthetic application
following topical oxazolone
following topical sensitization
following basic application
following topical diclofenac
following topical exposure
following topical estrogen
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