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First, following our general model validation work flow (Tropsha and Golbraikh 2007), we used 23 compounds excluded randomly from the entire data set as an external validation set.
For stalk tunnel length the proportion of genotypic variance explained by the QTLs following cross validation in our experiment was similar to that found by Papst et al. [ 34] and Ordas et al. [ 10].
Figure 3a demonstrates our experimental overview including the bioinformatics pipeline employed following quality validation of sequence reads.
Validation was performed following the ICH validation guidelines (International Commission on Harmonisation, 1996).
It is vitally important that predictive methods are developed that will be accepted, following thorough validation, by the composites engineering community.
It is composed of four steps with possible iterations following the validation of stakeholders.
No changes in classification were necessary following the validation study.
We suggest that following manual validation the hypotheses generated by SMILEY can guide experimental laboratory research.
Proxy tissue may in special circumstances be useful following deliberate validation (Talens et al. 2010).
Minor modifications were made following this validation procedure to improve the translatability of the questionnaire.
Of the 12 individuals six had identical genotypes following variant validation.
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