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In addition to the identification and further validation of established genomic events in medulloblastoma (e.g. MYC amplification, CDKN2A/B homozygous deletion [1], [2], [6] [8]), defects have been identified which will, following further validation, aid investigations of the critical genetic targets of common medulloblastoma chromosomal aberrations.
These fluorescence intensity-based pH indicators display robust responses and, following further validation and calibration, may provide facile alternatives to ratiometric-based pH indicators based on GFP [ 37].
Following further validation of its performance in other AD rodent models and nonhuman primates, Fluselenamyl could offer a platform technology for monitoring earliest stages of Aβ pathophysiology in vivo.
Following further validation, the signature may have clinical utility in combination with other host response signatures for diagnosing and managing patients with systemic inflammation.
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This fragment was elevated in the serum of patients with IPF or COPD, and may represent a novel method for detecting ECM in IPF and other chronic lung diseases, following further clinical validation [ 97].
The following further explains what we meant by validation.
The following further criticisms can be added.
SNPs that met the following criteria were selected for further validation: (1) SNPs with P ≤ 5.0 × 10-5 in GWAS stage; (2) when multiple SNPs showed strong LD (r ≥ 0.8), SNP with the lowest P value was selected and (3) MAF ≥ 0.05.
For this purpose, we have investigated the DNA methylation alterations following a microarray-based DNA methylation approach as well as pyrosequencing of selected genes for further validation.
Further validation might be gained in future studies that determine how responsive to change these measurements are following interventions.
Further validation of their non-malignant nature is found in the fact that none of the seven had recurrence following surgery.
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