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Importantly, there were no AEs observed following escalation to >30 mg/kg per d that were not observed at lower doses before escalation.
Nineteen (79%) patients developed a TR at the initial 150 mg per day dose level, whereas three (13%) and two (8%) patients developed a TR following escalation to 200 and 225 mg per day, respectively.
Forty-two patients (15·9%) had a serious AE following escalation to >30 mg/kg per d; those assessed as possibly drug-related were lenticular opacities, increased transaminases, gastrointestinal haemorrhage, abdominal pain and abnormal liver function tests (n= 1 for each).
Through week 256, 12 placebo and 19 50-mg patients increased the golimumab dose from 50 to 100 mg, and four placebo, 12 50-mg and 22 100-mg patients decreased the golimumab dose from 100 to 50-mg (following escalation to 100 mg in the case of placebo and 50 mg patients).
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Forty-two patiexperiencedenced a serious AE following dose escalation to >30 mg/kg per d, which was consistent with those observed prior to dose escalation and in the 1-year core trials (Cappellini et al, 2006; Galanello et al, 2006; Piga et al, 2006; Vichinsky et al, 2007; Porter et al, 2008; Taher et al, 2009) and typical of those expected in the target population.
Thousands of wounded servicemen returned to Japan following the escalation of Japanese military aggression in China in July 1937.
Regardless of survival, scores for the 23 participants were generally decreasing immediately following therapy escalation (p = 0.016).
However, following the escalation in geo-political risks recently, we feel that the underperformance is overdone as we still expect the European consumer to go on holiday.
A recent NOTAM put the eastern edge of Ukrainian airspace off limits up to 32,000 feet, following an escalation of military air operations in the region.
In August 2008, following an escalation of hostilities between Russia and Georgia over the separatist region of South Ossetia, Georgia announced its intention to withdraw from the CIS.
Delhi Pact, also called Nehru-Liaquat Pact, pact made on April 8 , 1950 following the escalation of tension between India and Pakistan in East Pakistan (now Bangladesh) after economic relations between the two countries had been severed in December 1949.
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