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The application of a dose fraction produces death of oxygenated tumor cells followed by oxygenation of hypoxic cells now more sensitive to the following dose fraction.
The primary efficacy response was time from randomisation to the first seizure following dose titration.
Among 10 pre-specified adverse events, only vomiting had significantly different incidence rates in the two vaccine groups following dose one (3% versus 13%, P=0.01) but the difference disappeared following dose two (4% versus 4%).
Among three derivatives, PHE, AMD and AMN, examined, AMD showed the highest inhibitory activity on LNCaP C-81 cell proliferation, following dose- and time-dependent manner.
Three blood specimens were collected (immediately before doses one and two, and 28±5 days following dose two) for measuring hemagglutination inhibition (HAI) antibody responses.
If LMWH is administered twice daily, either at the prophylactic or therapeutic dosage, 24 h must pass after catheter removal before proceeding with the following dose.
Differences in seroconversion rates following dose two between the two vaccine groups in pre-vaccination seronegative children were all <20% for the three vaccine strains (16% for H1N1, 0% for H3N2, and 0% for B).
In practice, the determination of peak serum levels performed 30 min after the infusion of aminoglycosides should be used, and then, the following dose should be adapted in order to reach the recommended threshold.
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These cells may be used to provide safe and effective haemopoietic rescue following dose-intensive chemotherapy.
Similar improvements observed in the ITT were maintained following dose-reduction.
The primary endpoint was based on immune responses following dose-1 of both vaccines.
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