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Three trials followed dose adjustment protocols based on serum PTH [ 20, 21, 24] or calcium [ 25].
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RDI was calculated as follows: (dose intensity/planned dose intensity) × 100.
Following dose optimization, subjects entered the 2-week double-blind treatment period.
However, the PGE-2 inhibition did not follow dose dependent pattern.
The flow of NaCl 20% was calculated as follows: Dose NaCl 2 0 % ml ∕ h = Natriuresis × Diuresis × 0. 3 3.
Titration was as follows: dose was increased by 50% if haemoglobin dropped below 10 g/dL or decreased by 25% if haemoglobin was above 12 g/dL.
Following dosing of EtPy at open circuit on Pt and Pd surfaces, adsorption was found to be structure sensitive with extensive chemisorption being exhibited at {1 1 0} and {1 0 0} terraces together with {1 1 1} × {1 0 0} and {1 1 1} × {1 1 1} steps.
Following dosing plan was adapted for the study.
Following dosing to steady state, 5 major metabolites are detectable in the serum.
Following dosing on day 6, subjects underwent a euglycemic glucose clamp study.
Following dosing, the animals were observed every 30 minutes for the first 4 hours.
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