Patients were excluded if data collection was impossible (for example because of a severe hearing or language impairment), if they had a short life expectancy, if they were awaiting nursing home admission, or in case of a definite indication for specific memory clinic follow-up (for example having been diagnosed with a rare dementia).
Patients who meet the following criteria will be excluded from the RCT: suffering from significant exercise limitations or comorbidities that would prevent a patient from following the required intervention in this study; and expected to be lost for follow-up (for example because of a planned change of residency).
Cases lost to follow-up, for example, emigrated, were included up to date last known to be alive.
Many words are used to describe loss to follow-up, for example, attrition, withdrawal and questionnaire non-response.
Patients will be offered continued participation should contraindications to imaging arise during follow-up, for example, pregnancy.
This trial will implement the practice of active follow-up, for example, by text messaging the patient for follow-up visits at regular intervals in the intervention arm.
Cases lost to follow-up, for example, patients who emigrated, were included up to the date at which they were last known to be alive.
Another missing data circumstance was when missing values occurred intermittently during study follow-up; for example, body weight and hence BMI.
We defined a suspected relapse as a situation in which a clinical, radiological or laboratory abnormality prompted an intensification of follow-up, for example, an additional follow-up visit or an additional radiological investigation.
We censored patients at the date of the occurrence of the first hypertension related outcome, date of death, date of loss to follow-up (for example, relocation), or end of study period.
This prompts a need for replication and scientific follow-up, for example, in examining the relationship between gene expression changes and protein expression and effects of BPA exposure in a wider range of estrogen-regulated target tissues.
