Sentence examples for folding signal from inspiring English sources

The total amounts of MFE-selected posinions in all serotypes were found to be significantly higher (p-value < 0.001; on average 40-100 foldependingding on serotype and the direction of the folding signal) than those obtained in the randomized variants.

So perhaps as many as 41% of the shuffled hits represent cases where the folding signal was simply not destroyed by shuffling.

A vector of FSCI values in all positions along the coding regions (Folding Signal Conservation Profile) was calculated by applying a 5 nt sliding window to the matrix of aligned MFE- profiles (for each serotype and folding signal direction separately), and calculating at each step the corresponding signal conservation index.

Positions with a significantly conserved strong folding signal were found to constitute 53, 65, 62, 66 different clusters in serotypes 1 - 4 correspondingly; likewise, weak local folding signal was identified as conserved in positions grouped in 49, 73, 58, 65 clusters.

We emphasize that conservation of MFE related signals was analyzed for each serotype, and folding signal direction separately; specifically, in each case we accounted for positions selected for only one folding direction, either strong or weak.

Moreover, as was stated above, the maximal FSCI value achieved in random is 0.2-0.42 whine in wild-type 35%-100%-100%FE-selected positions possessed higher conservation levels (depending on serotype and the direction of the folding signal).

The regions with significantly conserved strong / weak folding signals cannot be explained based only on sequence conservation.

We showed that positions with significantly conserved strong/weak folding signals are not likely to appear in random, thus suggesting that they were possibly selected in the course of viral evolution to fulfill certain biological functions.

Those positions with significantly conserved folding signals (p-value < 0.001 with respect to randomized selection conservation values, Benjamini-Hochberg false discovery rate = 0.001) which had conservation levels higher than achieved in all corresponding randomized variants were defined as positions that undergo a conserved evolutionary selection for strong/weak folding (MFE-selected positions).

MFE-profile of each wild-type sequence was compared in a position-wise manner to the MFE-profiles of the corresponding evolutionary-constrained randomized variants (randomized MFE profiles); positions with p-value < 0.05 were defined as "suspected" to have significantly more/less negative MFE in comparison to random (i.e. carrying a "suspected" folding related signal).

Conserved selection for strong / weak folding related signals cannot be explained basing only on dinucleotide composition.