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Meanwhile, crystallins have been taken as model proteins in the protein folding field for a long time.
Over the past three decades the protein folding field has undergone monumental changes.
As judged by a single publication metric, the activity in the protein folding field has been declining over the past 5 years, after enjoying a decade-long growth.
Upon surveying a small territory of its landscape, we find that the protein folding field is still quite active and many important findings have emerged from recent experimental studies.
It is the importance to the chaperone/protein folding field of the linker-mediated oligomerization that can lift this paper to eLife standards, especially if more direct evidence of that interaction could be included.
We review and contrast past and recent developments in the protein folding field.
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However more replicas changing the force-field, for instance using Amberff99SB-ILDN, would be a good option to gain more statistics and at the same time ensure to avoid the force-field dependence of the results, as in folding/unfolding processes it is very relevant (see for instance Lindorff-Larsen et al., 2012).
For those of you who've never been inside a campaign field office, a phone bank room is basically just a bunch of volunteers sitting at folding tables, calling their friends, relatives, neighbors, and basically anyone else they've ever met, asking them to commit to voting for the candidate in question, and maybe volunteer, or donate $5, depending on how the call goes.
http://dx.doi.org/10.1016/j.sbi.2012.11.009 In the fifty years since the protein-folding field was first established, there have been thousands of papers detailing the thermodynamic or kinetic characterization of hundreds of different proteins.
With a suavely relaxed, brushy touch Mr. Juarez covers free-standing folding screens and conventional canvases with loose, layered grids, impacted Cubist compositions and fields of cellular elements in palettes of subtle grisaille, lush pastel and high-keyed dissonance.
Small-scale turbulent motions in the gas repeatedly fold the magnetic field, which can grow by many e-foldings in a free-fall time.
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