Sentence examples for folding conformation from inspiring English sources

Nevertheless, the majority of evidences indicates that any mechanism promoting maintenance of the correct protein folding conformation or that enhances the clearance of huntingtin-containing aggregates represents a powerful therapeutic approach in HD.

A low RMSD throughout the MD simulation and consistent RMSD at the last of MD simulation indicated that the predicted tertiary structure of LPKC had acquired a stable folding conformation.

The newly identified mutation affected the D427 residue, which is highly conserved among species), and considering that this mutation is not found in other species, it is likely that aspartic acid is very important for intramolecular interactions for folding, conformation of malcavernin protein.

The sensing principle pertaining to the specific folding conformation described in this paper has the potential to serve as a general approach of using hairpin DNA aptamers to construct biosensors for other molecular analytes.

In this paper, based on the evolutionary Monte Carlo (EMC) algorithm, we have made four points of ameliorations and propose a so-called genetic algorithm based on optimal secondary structure (GAOSS) method to predict efficiently the protein folding conformations in the two-dimensional hydrophobic hydrophilic (2D HP) model.

These competing hypotheses are not mutually exclusive given the growing diversity in "on-pathway" and "off-pathway" protein folding conformations observed during amyloidogenesis [15].

We report the synthesis of six peptides (1 6), derived from the MccJ25 sequence, that are designed to form folded conformation by disulfide bond formation and electrostatic or hydrophobic interactions.

The 1H NMR, UV vis, and fluorescent investigations in chloroform revealed that, due to the intramolecular hydrogen bonding-driven preorganized folded conformation, the fullerene and pyridine units of the receptors are located with suitable spatial separation and consequently able to co-complex zinc porphyrin with remarkably increased stability.

Sfp by contrast retrieved simple straight-chain unsaturated carboxylic acids such as the all-trans eicosatetraenoic acid 22 at rank 2, a trend which was also present in Xfp analogs where topological distance perception favoured linear chain analogs, nevertheless many of these straight chain analogs presented a similarly folded conformation.

Another strict requirement for the development of a transmission blocking vaccine is the production of proteins in correctly folded conformation.

Thus, the poor solubilization yield obtained (e.g. with DDM) when the highest overexpression was reached might actually reflect the selective extraction of the population of BmrC/BmrD heterodimers in a correctly folded conformation.