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91 confirmed cases of hepatitis E were identified based on the presentation of HEV RNA, IgM or at least 4 fold rising of IgG levels.
Confirmed hepatitis E cases were defined as: 1) at least 4 fold rising IgG levels in paired sera; 2) RNA, confirmed by IgM; or 3) IgM, confirmed by low avidity IgG in acute phase serum.
91 cases of hepatitis E were confirmed based on the presentation of at least 4 fold rising of IgG levels, RNA, IgM or low avidity IgG (Figure 1 and Figure 2).
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Small (two fold) rises of cytosolic Ca2+ stimulated SERCA activity almost 10 fold [38,39].
Immune responses in both Japanese age groups showed significant pre/postvaccination fold rises for each serotype.
· Deaths in England and Wales involving heroin or morphine have increased nearly five-fold, rising from 187 in 1993, to 926 in 2000, according to the office for national statistics.
Even more striking, the number of surfers in California increased nearly 125-fold, rising from 7,000 in 1950 to 872,000 in 2013.
The Zagros consists of parallel limestone folds rising to elevations of over 3000 m amsl.
A positive MAT result was based on a 4-fold rising titer in 97 cases and a single titer of ≥1∶400 in 27 cases.
An 'IFAT confirmed' serological response was defined as a seroconversion or two-fold rising titre (0.3 loccurringccurring between acute and convalescent sera collected approximately 1 month apart on identification of IFAT positive NWs.
Four controls positive by both assays had scrub typhus based on a four-fold rising antibody titer defined using a standard immunofluorescence assay (IFA), while the remaining 10 positive controls had fever of unknown cause.
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