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A transformation from methyl to methoxy (Figure 7, row 4) has a small effect (~1.7 fold), reducing hERG binding in 17 out of 21 examples.
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Reactivity of RG7787 with sera from immunotoxin-treated patients was >1000 fold reduced.
Better absorption was confirmed by reduction in lipid profile with several fold reduced dose in mouse model.
The library provides parallel map and fold (reduce) higher order functions and targets standard cache coherent shared memory multi-cores.
Assuming a 100 fold reduced magnetic moment of the gold NP compared to an iron oxide NP, this would lead to a 104 fold reduction of the power deposited (10 mW per gram).
Expression of badh2 was found to be 9 to 30 fold reduced in both the scented rice cultivars than non-scented IR-64 at all developmental stages (Fig. 5c).
Also SMAR1 stable clone in B16F1 mouse melanoma cells showed 17 fold reduced invasion compared to control B16F1 cells (Figure 6C).
The most regulated genes are shown in table 2. AMP-DNM treatment of LepOb mice most pronouncedly effected expression of osteopontin/OPN (on average 20-fold increased in LepOb and 2.5-fold reduced upon treatment) and Ccl2 (on average 9-fold increased in LepOb and 2.5- fold reduced upon treatment (Fig. 5A, C).
In the analysis of single cell migration in a wound healing assay SMAR1 stable clone showed almost 2 fold reduced and siRNA treated cell showed 1.5 fold increased migration rate as compared to the control cells (Figure 6G).
In the absence of the trap, the DDX3ΔINS mutant showed a 2- fold reduced unwinding rate with respect to DDX3wt, while addition of the trap caused a 10-fold reduction in the unwinding rate (Table 3).
Due to ongoing cell death however (and likely a delayed entry into first division), the integrated areas of CFSE dilution were consistently smaller for the Coro-1A−/− T cells, indicating in the end a 2 3 fold reduced accumulation.
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