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After more than 6-fold radiation dose reduction by simply lowering the tube current, we observed a good correlation between the mean measurement values in LD and the ULD (more than six fold dose reduction), but a high level of noise in the ULD images which did not allow sufficient calculation of brain perfusion maps.
These results indicate that an average of 1.6-fold radiation dose is required to produce equivalent cell death in BxPC3 as in Panc-1.
Mice were exposed to 0.0002 cGy/min (~ 400-fold background radiation) continuously over 5 weeks.
Under these conditions, cells are up to three-fold more radiation resistant compared to oxygenated cells.
Among the 314 proteins quantified, 46 increased at least 1.3-fold after radiation treatment (Additional file 2: Table S1).
Dosimetric data indicate a 4-fold higher radiation absorbed dose to tumours for IgG compared with F ab' 2 fragments.
Additionally, 53 proteins were decreased at least 1.3-fold by radiation, most of which were identified as ribosomal proteins (Additional file 2: Table S2).
In line with this, upon miRNA-214 overexpression the already increased level of total p38MAPK was further augmented to 1.6-fold after radiation.
This result indicates that exposure to approximately 400-fold background radiation is not sufficient to affect radiation-sensitive genes in DNA damage response pathways, a finding consistent with the absence of a stress response.
These are respirable and the inhalation of Uranium involves a 200-fold increased radiation dose conversion coefficient (the committed effective radiation dose per unit intake) compared with ingested Uranium.
After exposure to approximately 400-fold background radiation for 5 weeks, we did not detect any significant changes in the levels of base lesions in spleen tissue from irradiated mice.
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