These procedures do not reestablish the vertical height of the vocal fold margin.
The exact inoculum dose was checked by culturing on blood agar plates and was within a 1.5 fold margin of the intended CFU dose of 500.
In fact, said, Mr. Wheeler, the head of the manufacturers' association, few devices reach that level because it was established with a 50-fold margin of error and the energy they need rarely reaches that threshold.
This generally represents around a 100-fold margin of safety from any known effects of the chemical.
HpyAV is equally active in MnCl2, CoSO4 and NiSO4 (specific activities are within a 2-fold margin for a 2-fold dilution series of the enzyme), and complete cleavage of λ DNA was not achieved in the presence of MgSO4, CaCl2, Cu OAc 2 or Zn OAc 2 at the highest enzyme concentration available (40 µmol of HpyAV on 0.3 pmol (1 µg) of λ DNA).
The sensitivity and specificity of this 30-fold margin for the prediction of TdP were 81 and 65%, respectively.
Therefore, it is preferable to employ dosages that provide at least a 100-to-1000-fold margin of safety (Juberg et al., 2009 ; Stagg et al., 2012 ).
The Committee noted that application of a 100-fold margin of safety would limit the use of some food additives yet was an adequate margin of safety for most substances proposed for use as food additives at the time.
The previously described 30-fold margin between hERG potency and therapeutic plasma concentration generally held true, however, it was apparent that in this analysis the hERG margin was not a perfect predictor of the classification.
With respect to the short-term human NOAEL (internal CPF dose of 150 μg/kg/day), the U.S. EPA has a 100-fold margin of exposure (MOE) target for occupational exposure due to interspecies uncertainties and variability (U.S. EPA 2006).
