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As summarized in Table 6, while the C/C genotype of this CYP11B2 promoter variant (-344T/C) is found in 20% of the overall Marin study population, it occurs in 48% of those with elevated PFRM risk, representing a significant 2.4 fold frequency enrichment associated with increased breast cancer risk in Marin (p < 0.0001).
Deployment tests show that the motion can be divided into three phases characterised by different types of folds, frequencies of oscillation and damping behaviours.
The higher-order terms of φ(t) lead to an n-fold frequency-domain convolution and the frequency-domain spreading of the data symbols.
The experimental TEG and the numerical simulation results show 25-fold frequency up-conversion and the power harvesting capacity of the SDOF TEG.
Most notably, the eggs microinjected with RFP-PH tended to display higher (more than two-fold) frequency of hemispheric impairment of vitelline layer elevation (see the egg labeled 'PH' in Fig. 7D), whereas the eggs microinjected with R40A behaved like the buffer-injected control eggs (Table 1).
It is clear that one should formally consider the effect of the Nyquist folding frequency.
This is equivalent to a 10- to 100-fold frequency increase over previously reported results (Huang et al., 2009; Zhou et al., 2012).
For R3, however, the evidence against stoichiometric symmetry is strong (X = 38; df = 3; P = 3 × 10−8), due to the large (1.9-fold) frequency difference between R3a and R3b, coupled with the moderate (1.2-fold) difference between R3c and R3d.
Furthermore these distorted markers are not randomly distributed throughout chromosomes: for example, a nearly linear gradient of distortion can be observed on linkage group 3 ranging from Mendelian equality of male and female markers to a 5-fold frequency in favor of male alleles.
One CRISPR-independent approach, which requires prior integration of the targeting vector by P-element mediated, achieved a ∼10-fold frequency improvement over the most recent CRISPR-independent protocol (Huang et al., 2009; Zhou et al., 2012) and reduced the number of false positives to very few.
Mice immunized with the higher Env expressing rMVAs had about 15-fold higher titers of Env antibodies and several fold higher frequencies of Env-specific CD8+ and CD4+ T cells than mice immunized with the low expresser.
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