Filled circles in cyan are folded foci.
If each independent mutation reduces the affinity for one or more potential bridging factors, simultaneous mutation of the TEN-domain and the TEL-patch should lead to an additive reduction of the fraction of nuclei that show co-localization of telomerase and OB-fold foci.
For the value of g FO = 9.5 mS/cm 2 that we considered, the onset of a spike is organised by the top fold F 3 of S. This fold contains a folded-focus singularity, but it is not accessible and the spikes are due to (regular) jump points.
20, 21 The efforts undertaken by synthetic biologists to construct orthogonal biological systems are two-fold, focusing either on the metabolism or on the biochemical building blocks.
Next we looked for evidence of heteroplasmic SNVs in 13 of the 46 patients who had a mean mtDNA read depth greater than 30-fold, focusing on heteroplasmy levels between 10 and 90%.
In a neighbourhood of the folded focus on the fold curve F 3, the slow flow has the form of large semi-cycles that cause the orbit segment to trace S 2 r laterally and, at the same time, push it toward F 3. Since the flow on the top sheet S 3 r also points towards F 3, as shown in Figure 7c,d, the orbit segment cannot pass F 3 and reaches a so-called jump point; compare also with Figure 6b.
With Zajac in the fold, the focus will turn to two other major offensive players, David Clarkson and Patrik Elias, who can be unrestricted free agents.
In this paper, we first discuss some of the methods used to speed up the process of detecting a fold bifurcation, focussing on designing test function methods to predict a performance index.
DOI: http://dx.doi.org/10.7554/eLife.07607.014 Given the unanticipated lipid kinase fold, we focused our mechanistic studies on the CylM dehydration reaction.
Initially, most of the scores used in structure prediction assessment aimed at the evaluation of the protein backbone or fold, thereby focusing on carbon α (Cα) atom positions.
Another study, performed on paired samples of brain and skeletal muscle from the same patients, showed 3.1-fold more foci in cortical neurons than in muscle (13).
